Integrative Biology Group is a part of the Bioengineering Department at the Faculty of Biology of Moscow State Lomonosov University.

Our focus is on integrating and applying modern concepts and approaches from physical and engineering sciences, computer science, molecular modeling, big data analysis and bioinformatics towards solving problems in biology and bioengineering. We aim at creating an environment where wet lab experiments, computer design, modeling and data analysis are synergistically integrated into cohesive reasearch and development pipelines.

Our News
• 15 Apr’21 - Dr. Alexey Shaytan has defended Doctor of Science thesis: “Integrative modeling of structure and dynamics of biomacromolecular complexes
• 16 Nov’20 - iGEM team from Moscow State University iGEM Moscow 2020 lead by Dr. Alexey Shaytan is awarded Gold medal at the prestigious International Genetically Engeneered Machine Competition. First iGEM medal for a Russian team in a decade! Congratulations!
• 13 Dec’18 - Congratulations to Grigory Armeev on successfully defending his PHD thesis: “Using molecular modeling methods to determine the structure of nucleosomes and their complexes with chromatin proteins”!
• 14 Feb’18 - We are delighted to join the synthetic biology community by becoming an iGEM lab
• 7 Nov’17 - Alexey Shaytan and group are highlighted by the Journal of Molecular Biology Career Advancement Initiative
Recent Papers
Histone dynamics mediate DNA unwrapping and sliding in nucleosomes, Nature Communications
Molecular Mechanisms of Oncogenesis through the Lens of Nucleosomes and Histones, JPC B
Structural interpretation of DNA-protein hydroxyl-radical footprinting experiments with high resolution using HYDROID, Nature Protocols
Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres, Genes and Development
Hydroxyl-radical footprinting combined with molecular modeling identifies unique features of DNA conformation and nucleosome positioning, Nucleic Acids Research
Coupling between Histone Conformations and DNA Geometry in Nucleosomes on a Microsecond Timescale: Atomistic Insights into Nucleosome Functions, Journal of Molecular Biology
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